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This new class of medicines blocks a protein called PCSK9, which interferes with the liver's ability to clear LDL cholesterol from bebenwirkungen bloodstream. Praluent is an injectable medicine only and is administered every 2 weeks. It will probably be recommended only for patients with heterozygous or homozygous familial hypercholesterolemia, the former occurring in 1 of 500 people 52 the latter in 1 in 1,000,000 people. The drug is expected to cost about 1000 monthly or 500 for each injection.

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Included in 1999 general and administrative expenses were: (i) legal and professional fees of 806,000, (ii) 717,000 in costs incurred on our HealthZone operations, (iii) 415,000 for consulting costs incurred to implement our acquisition of Inholtra and other products, (iv) approximately 1,136,000 in uncollectible receivables (v) 903,000 of non-cash warrant and compensation costs, and (vi) a 288,000 charge related to the relocation of our corporate and warehouse facilities. The prior year included 1,021,000 of costs associated with the merger described above. Distribution costs for the year ended December 31, 1999 increased 1,594,000 or 146, to 2,686,000 from 1,092,000 from the comparable period in 1998. The increase primarily relates to higher expenditures for freight, compensation, fulfillment and other distribution costs associated with efforts to promote new and existing products to new customers.]