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For example, the microemulsions can be used to deliver nitric oxide and TNF alpha inhibitors to a site of ecchymosis following cosmetic surgery such as rhytidectomy. Vitamin B 12, for example, is a useful nitric oxide chelator and is useful in reducing bruising, also known as ecchymosis. In one embodiment, the present invention contemplates a topical composition comprising a vitamin B 12 derivative (or analogs thereof) for the treatment of bruising. In a further embodiment, the present invention contemplates a topical composition comprising a vitamin B12 derivative (or an analog thereof) and a curcuminoid derivative (or an analog thereof) for the treatment of bruising.

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