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Reference to any prior art in this specification is not, and should not be taken as, an acknowledgment or any form of suggestion that this prior art forms part of the common general knowledge in any country. It is generally accepted in the art that delivery of therapeutic quantities of water-soluble macromolecules such as peptides and proteins or other such pharmaceutical agents across the skin is extremely difficult, as the skin functions as a barrier to prevent transdermal penetration of most water-soluble molecules. However, transdermal delivery is a highly desired method by which therapeutic amounts of peptides, proteins or other pharmaceutical agents could be administered particularly for local andor systemic therapy. This is because biologically-active macromolecules, such as certain peptides or proteins, generally have low oral bioavailability, making oral administration difficult, and often have short biological half-lives, making parenteral delivery impractical outside a hospital setting (Shahrokh et al. American Chemical Society, 1997). Additionally, there are many medical conditions and diseases of the skin, which would greatly benefit from direct local therapy, without exposing the other organs of the shah e madina female viagra to the deleterious side-effects of delivery via other routes. In this regard various pharmaceutical agents, such as non-steroidal anti-inflammatory drugs (NSAIDs), have been shown to have considerable gastric toxicity, thereby reducing their effectiveness. Additional side effects of NSAIDs include renal insufficiency and failure, gastrointestinal ulceration, bleeding or perforation, exacerbation of maalox wirkung viagra and congestive heart failure. Delivery of therapeutic pharmaceutical agents blandano agriturismo viagrande the skin addresses the above- mentioned problems by offering a number of potential advantages compared to conventional methods, such as pills and injections, including: shah e madina female viagra little or no degradation or modification of the pharmaceutical agents such as digestion of the proteins by the enzymes and surfactants resident in the stomach and small intestine; (2) an increase in drug effectiveness as the transdermal route avoids first pass metabolism by the liver; (3) minimization of gastrointestinal and other side effects caused by ingestion of the pharmaceutical agent; (4) an improvement in patient comfort and compliance due to a more user-friendly delivery method; and (5) the potential for prolonged and controlled drug ectomosol principio ativo do viagra. Current research into transdermal transport of water-soluble molecules focuses on: (1) using chemical enhancers to alter the skin's lipid environment; (2) using liposomes to facilitate transdermal transport; (3) using iontophoresis to provide an electrical driving force for transdermal transport; (4) using electroporation to create a new transdermal pathway; and (5) using ultrasound to create a new transdermal pathway.

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In Craig v. Pfizer, Inc.]