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Such diseases include neurodegenerative conditions like Parkinson's disease, Alzheimer's disease and other dementias as well as amyotrophic lateral sclerosis and multiple sclerosis. Other neurological diseases include those following acute injury such as stroke and spinal cord damage. Examples of agents which are useful in treating oxidative damage associated with neurological disease include NO chelators such as vitamin B 12 derivatives as well as inhibitors of NO synthase (e. Niacinamide, vitamin B12 and derivatives, curcumin and derivatives L-NAME 5 N 0 -nitro-L-arginine methyl ester; L- NMA, JV-methyl-L-arginine, L-NMMA, JV-monomethyl-L-arginine, S- Methylisothiourea sulphate, Aminoguanidine. 7-nitro indazole Inhibitro of nNOS, N-nitro-L-arginine). In a related embodiment, the present invention contemplates a topical composition comprising an NO synthase inhibitor for the treatment of acute CNS injuries such as stroke and spinal cord damage.

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