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Furthermore, to prevent the participating clinicians from being biased in treatments, they are not informed as to whether the treatment being administering is the topical pharmaceutical composition of the present invention or a topical placebo composition. Using this randomization approach, each volunteer has the same chance of being given either the new treatment or the placebo. Volunteers take part in a suitable exercise protocol to induce lower limb fatigue, for example, repetitive sets of jumping movements on an inclined sled apparatus on three separate days with a minimum of one week rest between each test session (presentation by S. Hughes at Australian Conference of Science and Medicine in Sport, Yanuca, Fiji, October, 2006).

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